Barium, A Cause of the Loco-Weed Disease Part 8

[137] Nelson, S. B. Feeding Wild Plants to Sheep. Bur. Animal Industry, Bul. 22, p. 12. 1898.

[138] Chesnut, V. K., and Wilc.o.x, E. V. Stock-Poisoning Plants of Montana. U. S. Dept. Agric., Div. Bot., Bul. 26, p.

95. 1901.--Wilc.o.x, E. V. Plant Poisoning of Stock in Montana.

Bur. Animal Industry, 17th Ann. Rept., p. 111. 1900.

NOTE.--The writer wishes to acknowledge the great literary help Mr. Chesnut's card catalogue has been to him in the preparation of this paper.

[139] Unpublished report.

[140] Marshall, H. T. Loco Weed Disease of Sheep. Johns Hopkins Hospital Bul., vol. 15, p. 182. 1904.

[141] Payne, J. E. Cattle Raising on the Plains. Colo. Agric.

Expt. Sta. Bul. 87, p. 16. 1904.

[142] National Standard Dispensatory, p. 868. 1905.

NOTE.--The field experiments of Harding and Tudor are rather conclusive as to the relation of these plants to this disorder. Sayre, L. E., Loco Weed, Amer. Vet. Rev., vol. 11, pp. 553-554, 1887--Blankins.h.i.+p, J. W., Loco and Some Other Poisonous Plants in Montana, Mont. Agric. Exper. Sta. Bul.

45, pp. 83-84, 1903--Loco Disease, Therap. Gaz., vol. 12, p.

30. 1898.

=NOTES ON VARIOUS MEMBERS OF THE LOCO-WEED FAMILY.=

_Astragalus caryocarpus_ is at times eaten in some of the Western States, but is claimed by some at certain stages of its growth to contain a poisonous principle. Frankforter,[143] from experiments on himself, however, denies this.

_Astragalus glycophyllus_ has been used as a diuretic and _Astragalus exscapus_ in the treatment of syphilis.[144] "The seed of _A. boeticus_, planted in Germany and England, are found to be the very best subst.i.tute for coffee yet tried, and so used--roasted, parched, and mixed with coffee."[145] _Astragalus nuttallia.n.u.s_, according to Smith,[146] is a highly nutritious forage plant in spring. _Astragalus cra.s.sicarpus_ has been prophesied by him to be a valuable addition to early spring soiling crops. _Astragalus adsurgens_ (_nitidus_) and one or two other species of Astragalus are still used in Chinese medicine.[147] The Indians of the Southwest are familiar with certain loco plants.[148] The Tewans of Hano are said to eat the root of _Aragallus lamberti_, and _Astragalus mollissimus_ is applied locally for headaches by some of the Arizona Indians. One of these species is used as a flavoring material by the Coahuillas and is mixed with other plants as spices.[149] _Astragalus kentrophyta_ had a reputation among the Navajos for the treatment of rabies.[150] The use of certain loco plants--_Astragalus mollissimus_--has been advocated on theoretical grounds in the treatment of certain forms of insanity, but without favorable results.[151] In Peru and Chile _Astragalus garbancillo_, _A. unifultus_, and _A.

ochroleucus_ have been considered injurious to animals.[152] _Astragalus glyciphyllus_ and _A. alpinus_ have been used in Europe as food for stock.[153]

Details as to the use of other Astragali can be found in Planchon, G., Sur les Astragales, in Journal de Pharmacie et de Chimie, 5th series, vol 24, p. 473, 1891; 5th series, vol. 25, pp. 169, 233, 1892.

FOOTNOTES:

[143] Frankforter, G. B. A Chemical Study of Astragalus Caryocarpus. Amer. Journ. Pharm., vol. 72, p. 320. 1900.

[144] Maisch, J. M. Poisonous Species of Astragalus. Amer.

Journ. Pharm., vol. 51, p. 240. 1879.--Fleurot. Chimiques et Pharmaceutiques sur la Racines d'Astragale sans Tiges. Journ.

de Chim. Med., vol. 10, p. 656. 1834.

[145] Porcher, F. P. Resources of the Southern Fields and Forests, p. 204. 1869.

[146] Smith, J. G. Fodder and Forage Plants. U. S. Dept.

Agric., Div. Agrost., Bul. 2 (rev. ed.), p. 12. 1900.

[147] Holmes, E. M. Notes on Chinese Drugs. Pharm. Journ. and Trans., vol. 21, 3 s., p. 1149. 1891.

[148] Hough, W. Environmental Interrelations in Arizona.

Amer. Anthropologist, vol. 11, pp. 143, 147. 1898.

[149] Barrows, D. P. Ethno-Botany of the Coahuilla Indians of Southern California, p. 67. 1900.

[150] Matthews, W. Navajo Names for Plants. Amer. Nat., vol.

20, p. 772. 1886.

[151] Givens, A. J. Loco or Crazy Weed. Med. Century, vol. 1.

p. 21. 1893.--Compare Hurd, H. M. Amer. Journ. Insanity, vol.

42, p. 178. 1885-86.

[152] Rosenthal, D. A. Synopsis Plantarum Diaphoricarum, Erlangen, 1861, p. 1004. Greshoff, M. Beschrijving d. Giftige en Bedwelmeude Planten bij de Vischvangst in Gebrulk, p. 51.

1900.

[153] Pott, E. Handb. d. tierisch. Ernahrung, vol. 2, p. 113.

1907.

=LABORATORY EXPERIMENTS--PHYSIOLOGICAL.=

The first point in our investigations was to determine whether the plant exerted any poisonous action and to find some animal which responded regularly to it; then to ascertain if the lack of results of previous investigators was not due to insufficient doses, and later to see if by feeding smaller amounts at repeated intervals symptoms comparable to those described as occurring on the range could not be produced. The animal finally selected was the rabbit.

=EXPERIMENTS ON RABBITS.=

=ACUTE CASES.=

_Experiment No. 1._--On September 8, 1905, an aqueous extract of 333 grams of fresh _Astragalus mollissimus_, made in Hugo, Colo., and s.h.i.+pped preserved in chloroform,[154] killed a rabbit weighing 1,616 grams in one hour and thirty-five minutes, while an extract corresponding to 167 grams merely caused drowsiness and loss of appet.i.te in a rabbit weighing 765 grams.

_Experiment No. 2._--On November 29, 1905, a rabbit weighing 1,162.3 grams was fed with a concentrated aqueous extract of 500 grams of fresh _Astragalus mollissimus_, which had been s.h.i.+pped from Hugo, Colo., preserved in chloroform in sealed vessels. This animal died in one hour and ten minutes. The symptoms consisted in dullness, rapid respiration, and signs of pain. At autopsy the stomach and upper part of the small intestines showed hemorrhagic ecchymoses, with dilation of the dural vessels of the brain and cord, with a clot over a portion of the spinal cord.

_Experiment No. 3._--On February 13, 1906, a rabbit weighing 992 grams was fed with a concentrated aqueous extract of 500 grams of the fresh _Astragalus mollissimus_, collected in September and preserved in chloroform water. Before feeding, the rabbit's ears were warm and the rabbit struggled when any attempt was made to turn him on his back. The temperature at 10.50 a.m., the time of feeding, was 103.5F.; at 11.15 a.m., 102.5F. At 11.30 a.m. the rabbit was breathing very rapidly and would stay on his back for some time if placed so. The temperature at this time was 102.6F. Both pupils, the one exposed to the light and the one protected, were contracted. At 12.02 p.m. convulsive movements of the legs appeared. The rabbit made one leap, the temperature rose to 103.6F., and after a few convulsive movements of the limbs the a.n.u.s relaxed and a small stool appeared, the pupils dilated, and the animal died at 12.06 p.m.

_Experiment No. 4._--The feeding of the extract of 464 grams induced a fall in temperature of 2.4F. in three hours, and the rabbit died several hours later (at night).

_Experiment No. 5._--March 2, 1906, a rabbit weighing 928 grams was fed with a concentrated extract of 500 grams of the fresh seeds and pods of _Astragalus mollissimus_, made in September, 1905, and preserved with chloroform water. This animal died in one hour and seven minutes. The animal showed the usual post-mortem conditions.

It was thus found that the aqueous extract of 500 grams of the fresh _Astragalus mollissimus_ would cause death in about one hour in rabbits weighing about 2 pounds (907 grams), these rabbits showing constant clinical symptoms--urination, paralysis, more or less convulsive muscular twitchings, often terminating in general convulsions, drowsiness, and stupor, with more or less anesthesia. The pupils at the time of death were often unequal. At first there was usually a slight rise in temperature, but this was soon succeeded by a fall. Often there were soft stools. The post-mortem lesions in these cases were marked congestion, with hemorrhages in the stomach walls and a secretion of thick mucus. The portions of the stomach walls most affected were the dependent portions near the cardiac end. The intestines showed dilatation of the blood vessels. The mesenteric vessels and also the vessels in the cerebral portions of the dura were markedly dilated; in some cases there were clots, especially at the posterior portion of the brain, between the cerebrum and the cerebellum. At times there were clots over the dorsal portion of the cord. On cutting into the brain the brain substance itself did not appear to be congested. The cord seemed about normal, but the vessels of its membranes were well marked. The other organs showed nothing characteristic macroscopically. These experiments were repeated many times and found to be constant.

These acute symptoms were likewise produced by an extract of 500 grams of the fresh _Aragallus lamberti_ from Arizona preserved in chloroform water (rabbit weighing 1,998 grams). An aqueous extract of 150 grams of the dried _Astragalus mollissimus_[155] from Imperial, Nebr. (1906), caused death in one hour and fifty-eight minutes in a rabbit weighing 1,530 grams, and an extract of 100 grams killed in one hour and twenty-two minutes a rabbit weighing 736 grams.

An aqueous extract of 100 grams of the dried _Astragalus bigelowii_ induced death in one hour and thirty-eight minutes, the rabbit weighing 1,502 grams.