The Glands Regulating Personality Part 23

The nature of the researches? They would be infinite in their variety and significance. Their practical by-products, dropped in the pursuit of knowledge by the scientist, as Atalanta's lover the golden apples in his race, to a.s.suage the scent of the hard-headed business man, would be profitable enough for any country in peace or war, to pay for itself ten times over and at compound interest. A volume could be filled with suggestions for interesting and promising investigations.

But we may glance at some of the immediately useful aspects that might exercise those concerned with the everyday life of men, women and children.

THE ENDOCRINE EPOCHS OF LIFE

There is no more famous cla.s.sifications of the epochs of life that mark off the milestones of the individual's evolution than Shakespeare's Seven Ages. So different is he at those different stages of his development, so changed his body and mind that it has become a part of popular physiology that we are entirely made over every seven years, and that no cell in the organism lasts longer than that. The tradition certainly does not apply to the brain and nervous system, for the number of brain cells is fixed at birth, and cannot be increased, only decreased, because they are too highly specialized to reproduce themselves.

What transfigures the individual as the years go by is no simple wear and tear of the tissues, nor the replacement of old cells by new. It is the rearrangement of relations.h.i.+ps among the ductless glands, the s.h.i.+fting of influences from the predominant to the subordinate, and vice versa, in the constellation of the internal secretions, that determines the unfolding of the personality. The transformations raise doubt sometimes as to the reality of personal ident.i.ty. What actually happens in the changes from childhood to adolescence, from adolescence to maturity, and so on, is the sloughing of one internal glandular dominance for another.

Growth, as a general name for the mutations, the ensemble of somatic and psychic differentiation, from year to year, pa.s.ses through five epochs that are standard for the normal. The normal is the being who harmonizes with his environment, and yet reacts with it because of recurring needs within him. His endocrine equation settles what is unique and different in him. But the gland which flourishes during the epoch as its time of triumph, when it has its day, determines what makes him like his fellows.

From this point of view it becomes permissible to speak of the five Endocrine Epochs. Similarities and resemblances of mind and body between people at a given period of life, childhood, youth, maturity must be put down to their common government by the salient endocrine of the epoch. So one may list:

Infancy as the epoch of the thymus Childhood as the epoch of the pineal Adolescence as the epoch of the gonads Maturity as the epoch of whatever gland is left in control as the result of the life struggle.

Senility as the epoch of general endocrine deficiency.

Infancy as the epoch of the thymus explains why, in any given geographic locality, the babies look alike and act alike. Specialists in the observation and treatment of infants have noted that not until after the second year is any tendency to differentiation discernible to any extent among them. It is only after the second year, or somewhere around that time, that the child begins to individuate, and distinct individual traits and a personality manifest their outlines.

The thymus is the great inhibitor of all the glands of internal secretion. By its checking activity upon the other members of the endocrine system, the thyroid and pituitary in particular, it gives the baby time to grow in bulk, which is its chief business during the first two years of its existence. It quadruples its birth weight. The brain and nervous system complete their growth in ma.s.s by the end of the fourth year. Recall the experiments of Gudernatsch working with tadpoles, who showed that feeding with thymus produced giant tadpoles whose metamorphosis into frogs was inhibited, while feeding thyroid produced frogs the size of flies. Differentiation occurred without the preliminary increase in ma.s.s usual. As differentiation and bulk thus appear antagonistic, at least at the beginning of growth, the function of the thymus, at a maximum during infancy, seems then to be to restrain the differentiating endocrines, until sufficient material has been acc.u.mulated by the organism upon which the differentiating process may work.

After the second year, the thymus begins to shrink. That is to say, officially its involution begins. Careful dissection will demonstrate some thymus tissue even in a normal subject up to the fourteenth year.

This refers to the average normal, for the large thymus may continue large and grow larger after the second year in the type of individual designated in a preceding chapter as the thymocentric.

If the thymus retrogresses after the second year, what takes its place as a brake upon the forward driving impulses of the other endocrines?

We have every reason for a.s.signing that role to the pineal. It performs its service mainly, in all probability, by inhibiting the s.e.x stimulating effect of light playing upon the skin. Since it is especially a s.e.x gland inhibitor, the thyroid and pituitary become freer to exert their influences than under the thymus regime. And so we find that it is after the second year that thyroid and pituitary tendencies manifest their effects. The Pineal Era, from the second to the tenth to fourteenth years, remains to be investigated from a number of viewpoints interesting to the parent, the educator, and the student of puericulture. Precocity is directly related to early involution of the pineal. For just as the thymus involutes at the second year, the pineal atrophies before the onset of adolescence.

Adolescence is the period of stress and strain throughout the somatic and psychic organism because of the volcanic upheavals in the s.e.x glands. The history of the individual is dominated by them up to twenty-five or so, when maturity commences in the sense of a relative s.e.x stability. They continue to exert a powerful pressure throughout maturity. But life episodes and crises, diseases, accidents, and struggles, experiences of pleasure and pain, as well as climatic factors, settle finally which endocrine or endocrines are left in control as a consequence of the series of reactions the period of maturity may be a.n.a.lyzed into.

THE INTERPRETATION OF SENILITY

Senility inevitably follows maturity, not as night follows day by a mathematical necessity, but because of the process of degeneration which ultimately overtakes all the glands of internal secretion, dominant as well as subordinate. Just why the degeneration must occur no one can say. Injury to the endocrine organs of one sort or another, ranging all the way from emotional exhaustion to bacterial infection, is the reason usually considered sufficient. Just why recuperation and regeneration do not preserve them in the elderly as they do in youth is a problem to be solved when we understand the laws of regeneration, at present almost totally beyond our control. Some say that it is a matter of the wear and tear of our blood vessels, those rubber-like tubes which transport food and drainage with nonchalant equanimity to all cells as long as they last. In the cla.s.sic phrase: a man is as old as his arteries, ergo his ductless glands will be as old as their arteries. And the age of arteries is simply a matter of wear and tear, the resultant of the function which is universal among molecules.

Arteriosclerosis, the hardening of arteries, might be the whole story.

But there are certain experiments and considerations which rather confute that easy explanation, or at least make clear that the mystery is not so simple. The work of Steinach, a Viennese investigator, has contributed most to the elucidation of the nonarterial factor in senility. No one has a.s.serted more loudly the importance of the interst.i.tial cells that fill in the s.p.a.ces between the tubules of the testes in the male, and the follicles of the ovary in females. Rats have been his medium of study, for they are most easily procurable, live fastest, breed, and withstand experimental and operative procedures better than any other animal.

An old rat is like an old man in his dotage. His bald, shrivelled skin covers an emaciated body. His eyes are dimmed by cataracts and his breathing is labored and difficult because his heart muscle has lost its tone. Huddled in a corner, life to him has become concentrated into the desire for a little food, and immobility. If now, something is done to his s.e.x apparatus, a marvelous transformation may be effected. That something no one could predict. It consists in slitting the genital duct, which leads from the germinal cells to the exterior.

After the operation, the germinal cells, which grow into the spermatozoa, atrophy and disappear, since they can no longer function.

As if released from some restraint, the interst.i.tial cells, however, multiply enormously. With their multiplication, the miracle of rejuvenation is performed.

After some weeks the sluggish currents of being in the rat, which had slowed down as a preliminary to stopping altogether, flow fast and furious. Waves of new chemical substances inundate his cells. And they respond like the fields that border the Nile after the annual flood.

All his tissues, skin, muscle, nerve, even bone, are restored. A vitality is created which makes him bound and dart like a youth of his species. In due time, though, senility returns. It is as if a storage battery, recharged, runs down and becomes dead again. Slitting the genital duct of the other testis, causing its interst.i.tial cells to hypertrophy and multiply, repeats the effects of the first experiment.

The organism responds again to the new waves of vitality that vibrate through it. That it is recharged is demonstrated again by a revival of s.e.x appet.i.te and s.e.x activity. The female which had become an object of indifference is reinstated as a creature to be sought and pursued.

The second period ends in its turn. And now entirely new interst.i.tial glands, in the form of fresh testes removed from a young animal, are transplanted into the body of the old rat. Once more youth returns.

But now it burns itself more quickly than even before. An acute exhaustion of the mind appears first. Then all the other phenomena of old age steal back upon the old rat, and senility, firmly established in the saddle, rides him to the end.

THE POSSIBILITIES OF REJUVENATION

Whatever other deductions may be extracted from these experiments, they prove beyond a doubt the existence of an endocrine factor in the process of aging, as well as an arterial. They also demonstrate that the internal secretion of the s.e.x glands, well advertised as it has been as the Elixir of Youth that Ponce de Leon, and Brown-Sequard with so many others, pursued in vain, is not the whole story. For if it was, the duration of the new youth should be another span of life, whereas in actuality it is only a fraction of that time. This fact, together with a number of others, make clear that while the gonads may be the jeune premier of the drama, the vitality of the plot depends upon the other endocrines. Since old age is an exhaustion, permanent and irreparable of _all_ the members of the ductless gland directorate, the reason becomes clear for the temporary quality of the rejuvenation effected by the procedures of Steinach.

Practically, then, the question at once arises: which of the glands in particular are involved? There is first that ubiquitous agent in the system, the thyroid. Chemical a.n.a.lysis of it has shown that the iodine content decreases with the age of the individual, and becomes specially low after forty. It is after the menopause in women that myxedema, the disease of complete degeneration of the thyroid, and of the physical and mental faculties, is most frequent. The thyroid of old people exhibits, in varying degrees, signs of a similar degeneration. Thyroid feeding, properly controlled, will clear up certain of the deteriorations of mind and body observable in the aged.

The grossness of the features lessens, a number of the pains go, muscular endurance increases, memory and intelligence do not remind one so forcibly of the old dotard in his second childhood. Of course the improvement at present achievable is only relative. But in the prematurely aging, decay invading a half accomplished maturity, marvels have been achieved at times with feeding of the gland.

The pituitary, too, begins to retrogress after the period of maturity.

And an early retrogression means a short maturity. In women, the onset of an obesity, and coincidently, of a lazy and dull morale, coincides with this declension of the pituitary powers. All the glands of internal secretion, in fact, shrink and shrivel as old age advances.

Only, as in other relations.h.i.+ps, the predominating endocrine stamps its signature more visibly upon the doc.u.ments of decadence than the others. Pituitary types, as said, get fat and slow, thyroidal become bulky and stupid or thin and sour, the adrenal dark, shrunken and forever tired of life. So type emerges, even in all-around glandular deficiency.

The problem of rejuvenation is the problem of recharging, or replacing all of the glands of internal secretion, at least the most important, the thyroid, the pituitary and the adrenals, as well as the gonads.

Longevity is perhaps largely a matter of preventing, or postponing their wane. Beside, there is the prophylaxis of bacterial infections, and their all embracing corrosions--which, too, have an endocrine aspect.

Persistence of youth or juvenility may be manufactured by nature in two ways. There may be a persistence of early glandular predominances.

We have seen what happens to the thymocentric. That a pineal-centered juvenile or infantile type exists may be safely predicted. Nature's only other mode of securing perpetual youth seems to be by prolonging the time allotted to the s.e.x gland crescendo.

As for the golden age of maturity itself, what humdrum people and poets have despised as middle age, the margin of reserve of the ruling hormone is a quant.i.ty almost malleable in our hands, but still to be regarded with respect as a hard cold proposition by the physiologist.

In general, the continuance of any stage of development means the maintaining of the glandular administration peculiar to it. So the chubby debonair irresponsible whom nothing can touch is happy in the possession of a pineal uncorrupted by the years, while the genius who can turn out his best work at sixty-five must thank his pituitary for standing by him to the end.

THE SCIENCE OF PUERICULTURE

There is a specialty now growing in the womb of science which in its own good time will come to fruition as the study of the child's needs or puericulture. Even today there exists a scientific basis for the formulation of the principles upon which every child should be brought up. Though we have had marvelous results from the campaigns to lower infantile mortality, most of what has been done has been medical in its interest, and so largely negative in its accomplishments. The removal of the causes of evil no doubt gives the good its opportunity.

But how to raise a child, endowed with satisfactory ancestral stuff, as a Grade A normal or supernormal, still remains to be erected into an exact science.

A number of attempts have been abortive in this field. Why they have failed to arouse the ardor of the parent has puzzled some of the pioneers. Child-culture as the foundation of all systems of education has continued more or less of a hope rather than an achievement because of a lack of appreciation of the different const.i.tutional varieties of children. A certain amount of attention has been lavished upon children needing special attention, those mainly suffering from insufficient development of one sort or another. In the last decade or so, an endeavour to focus upon the exceptional child, exceptional in intelligence or some special creative endowment, has started an interesting movement. All of them have suffered from the fallacies and troubles of the pure psychologist who would handle mind as an ent.i.ty in a vacuum.

A realization of the different physical and psychic educational needs of various children will arrive only when we see them as built differently. Just as shoddy and silk, cotton and wool, alone or in combination, all possess different qualities as wearing material, so different children have varying capacities for the wear and tear of education. The endocrine cla.s.sification of the human race, applied to children, will here yield a harvest to the educator and to the country. Nothing is more evident than the diversified nature of the needs of the various internal secretion types, once they are realized as such.

The history of a thymocentric type, for instance, is predictable from the very first few months of his life. Difficulties in feeding, in habit formation and adaptation, in the reaction to infections, in social play and so on, one may expect for him. The course of events for the other endocrine types also follow laws of their own. It will be above all in the _understanding_ of children, their make-up, reactions and powers, that the biologist will achieve some of his finest triumphs.

The educator will have to take account of the state of the pituitary in estimating the normal intelligence, or influencing the abnormal or subnormal intelligence. As well will he have to consider the thyroid in the child whose conduct is refractory, even though his proficiency in his studies is excellent. And the condition of the adrenal will be ascertained in the types that tire easily, and that seem unable to make the effort necessary or desirable. Periodic seasonal and critical fluctuations in the equilibrium among the hormones will have to be taken into account in the explanation of what have hitherto been put down to laziness, naughtiness, stupidity, or obstinacy.

A child's capacity for education, essentially its capacity for the highest and most productive kind of life, is limited by inherent factors. These factors are two: the quality of the nerve tissue, its ability to make a number of a.s.sociations, and the quant.i.ty of the internal secretions, measured by the maximum obtainable in a given situation. These inherent factors explain, too, why children born and bred in virtually the same environment show the most extreme differences in educability. That the differences are inherited was made evident by Galton's finding that the chance of the son of an eminent man exhibiting eminent ability was 500 times as great as that of the son of a man taken at random.

Every baby, then, is born with a combination of nerve cells and ductless glands which determine its capacity for mental development, that might never be realized, but could never be exceeded. If, in any family, minor differences in educability are observed, they can be put down to disturbance of these two factors occurring after the fertilized germ cell had started to divide and reproduce itself. But any marked falling off in either the nervous or endocrine factors has to be considered pathologic, due to an impairment of them by adverse environment.

Recent studies have amply established that the proportion of certifiable mental defectives, and of a much larger cla.s.s, the subnormal but not certifiable cla.s.s, is progressing by leaps and bounds. It is perhaps the most absurd frailty of our present system of education that it takes almost no account of innate differences in educability. To spend money upon the teaching of these children along lines where they are unteachable is not only waste pure and simple, but crime, for it deprives the educables of their just due.

These, of course, are the crude and simple lines upon which the finer and more complex evolution of the endocrine problems of the school child will build. The fine art of education itself is crude and gross and simple compared with what it might be, even as a beginning. The science of education has yet to begin, as the offspring of that science of the future, to which knowledge of the internal secretions will contribute no little, the science of puericulture.

VOCATIONAL EDUCATION

It is difficult, indeed, to avoid becoming merely enthusiastic upon the possibilities of the applications of the endocrines to the educational domain. Happiness for the average individual consists of a double success--success in his vocation (chosen or forced upon him) and success in his s.e.x life. A certain hue and cry has been raised in the last few years concerning the vast and overwhelming importance of s.e.x in the happiness and even in the successes of a man's everyday life. And no doubt there is a relation. Sublimation plays its part in the explanation of vocational idiosyncrasies. The fact, however, that perfect success in s.e.x may occur with absolute failure in the career, however, splits the problem for good into its realities: a physiologic aspect as well as a psychologic.

So, as school education will have to take serious account of endocrine anomalies and possibilities, will the inst.i.tution which selects and trains for a career. Vocational misfits have aroused the ardor of our efficiency experts. And again, the sweeping psychological attack has beaten its head against the stonewall of ignorance of const.i.tutional predispositions and tendencies of material. The attempt to erect psychologic types for vocational selections could never make much headway because it could only flounder in a swamp of metaphors, product of the vices of its methods. Not that anyone would wish to discard at all the psychologic mode of approach. But no science, in the sense of accurate examination, was possible, in the matter of cla.s.sification for vocation, without the insight into the physiology of the candidate that the a.n.a.lysis of his endocrine formula will provide.

One need not dilate upon the value of such an examination.

Civilization has not yet learned how to pick its personnel. And so artists and scientists, philosophers and politicians, financiers and religious leaders, arise and survive by the operation of the laws of probabilities and chances, rather than by any intelligent selection and cultivation of material. The case, indeed, is simply a subdivision of the vast subject: haphazard muddle in the conduct of life. A cry has been raised for the superman, and a cry has been raised for a method of anthropometry. For the lack of these two, it has been said, all governments have been doomed to defeat. The study of the endocrines will by no means supply a panacea. But as it will furnish a means of approach to the determination of how men and women are built, and why they are built differently, no one can gainsay the tremendous advantages to the nation that will proceed to cla.s.sify its population accordingly, and know its strength and weakness in terms of the actual generators of success and failure.

Suggestions have been offered in the preceding pages of concrete applications of endocrine knowledge to the understanding of behaviour, of the genius and commonplace, criminal and Puritan. And in the chapter on historic personages, we tracked some of the story in detail. This vein when explored will quarry untold riches. It has been observed that financiers of mark, like great musicians, are special pituitary types. Also that the financiers are voracious meat eaters and the musicians inordinately fond of sweets. Differences in anterior and posterior predominances might account for this. That we are playing here with no phantasy is proven by the fact that we can effect changes of tastes as well as of intellectual direction by appropriate feeding of various glandular extracts. Just as much, indeed, as we can influence s.e.x susceptibility, and the reaction to s.e.x stimulation, by the artificial introduction from without of the proper hormones.

FATIGUE AND INDUSTRY

In industry, business and profession, the biologist will come more and more to be called as consultant. Labor unions as well as the large employers of labor, and their employment managers have given much thought to the problem of fatigue. Just what fatigue is, why different individuals tire at different rates, why some are constructed for monotonous routine while others must have constant variety and change, the relation to accidents and to quant.i.ty output, are a few of the major lines of inquiry upon which the endocrines obviously have a large bearing. To the employment manager, labor turnover and the selection of personnel are adjacent fields of research.